Indications

Respamox is indicated for  the following infections:
l Sinusitis
l Community-acquired pneumonia
l Bronchitis
l Pelvic inflammatory disease or complicated skin and soft-tissue infections which have failed to respond to other antibacterial or for patients who cannot be treated with other antibacterial

Pharmacology

Moxifloxacin is a synthetic broad spectrum flouroquinolone derivative antibacterial agent. It exerts activity against a wide range of Gram-positive, Gram-negative, anaerobic and atypical bacteria including Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pneumonia, Haemophilus parainfluenzae, Klebsiella pneumonia, Moraxella catarrhalis, Staphylococcus aureus, Streptococcus pneumonia, Chlamydia pneumoniae, Mycoplasma pneumonia, Bacteroides fragilis, Bacteroides thetaiotaomicron, Clostridium perfringens, Enterococcus faecalis, Escherichia coli,  Proteus mirabilis, Streptococcus anginosus. The bactericidal action of Moxifloxacin results from inhibition of the topoisomerase II (DNA gyrase) and topoisomerase IV required for bacterial DNA replication, transcription, repair and recombination.

Dosage

The recommended dose of Respamox is 400 mg once daily. The duration of therapy depends on the type of infections as described in the following table.

Indications  Dose  Duration
Community Acquired Pneumonia 400 mg once daily  7-14 days
Exacerbation of chronic bronchitis  400 mg once daily  5-10 days
Acute Bacterial Sinusitis  400 mg once daily  7-10 days
Pelvic inflammatory diseases  400 mg once daily  14 days
Skin and soft tissue infections  400 mg once daily  7-21 days
Community Acquired Pneumonia in    400 mg once daily   7-14 days
Hospitalized Patients
Complicated Intra-abdominal  400 mg once daily  5-14 days
Infections  

No dosage adjustment is required in patients with renal or hepatic impairment.

Interaction

Antacids, sucralfate, multivitamins and other products containing multivalent cations reduces the absorption of Moxifloxacin. Therefore, Moxifloxacin should be taken at least 4 hours before or 8 hours after taking these agents. Quinolones, including Moxifloxacin have been reported to enhance the anticoagulant effects of warfarin or its derivatives in the patients population. NSAID may increase the risk of CNS stimulation. 

Contraindications

Respamox is contraindicated in persons with a history of hypersensitivity to Moxifloxacin or /and any component of this formulation.

Side Effects

Most side effects reported with Moxifloxacin treatment are mild to moderate in nature and require no treatment. Most common adverse reactions are nausea, diarrhoea, headache and dizziness.

Precautions & Warnings

Moxifloxacin should be discontinued at the first appearance of a skin rash or any other sign of hypersensitivity. Moxifloxacin should be discontinued if the patient experiences pain, swelling, inflammation or rupture of a tendon.

Storage Conditions

l  Store in cool & dry place, protected from light
l  Keep out of reach of children